GABAA receptor modulator-13 is an orally active, blood-brain barrier-permeable alpha4beta1delta GABAA receptor modulator (IC50 = 9.02 µM). GABAA receptor modulator-13 reduces GABA-induced currents, impairs the stability of the transmembrane domain M2-M3 loop of alpha4beta1delta GABAA receptors, and exhibits selectivity for gamma2-containing GABAA receptor subtypes and alpha6beta3delta GABAA receptor subtypes. GABAA receptor modulator-13 is applicable to the research of nervous system diseases with altered tonic inhibition, such as neurodevelopmental disorders and epilepsy[1].
Molekulargewicht:
364.83
Formel:
C20H17ClN4O
Target-Kategorie:
GABA Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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