ULK1-IN-4 (compound 12i) is a ULK1 inhibitor with an IC50 of 4.7 µM against human ULK1, and it exhibits selectivity for Aurora A/Aurora B kinases. ULK1-IN-4 forms a covalent bond with the thiol group of the Cys182 residue of ULK1, thereby inhibiting the kinase activity of ULK1. ULK1-IN-4 inhibits the growth of colorectal cancer cells and exerts tumor-suppressive activity in a mouse model of colorectal cancer[1].
Molekulargewicht:
533.02
Formel:
C29H29ClN4O4
Target-Kategorie:
ULK
Anwendungsbeschreibung:
MCE Product type: Reference compound
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