Bcl-2/Mcl-1-IN-5 (Compound S6) is a Bcl-2 and Mcl-1 inhibitor. Bcl-2/Mcl-1-IN-5 promotes Apoptosis, downregulates anti-apoptotic proteins Bcl-2 and Mcl-1, induces mitochondrial membrane potential depolarization, and activates the Caspase-dependent apoptotic cascade, as evidenced by Caspase-3 activation and PARP1 cleavage. Bcl-2/Mcl-1-IN-5 has anti-hepatocellular carcinoma activity[1].
Molekulargewicht:
680.68
Formel:
C38H42BrN5O2
Target-Kategorie:
Apoptosis,Bcl-2 Family,Caspase,PARP
Anwendungsbeschreibung:
MCE Product type: Reference compound
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