PROTAC CBP/p300/BRD4 Degrader-1, CAS [[3109024-12-3]] Preis auf Anfrage
Artikelnummer:
MCE-HY-181758
Hersteller Artikelnummer:
HY-181758
Alternativnummer:
MCE-HY-181758-1UNIT
Hersteller:
MedchemExpress
Kategorie:
Biochemikalien
PROTAC CBP/p300/BRD4 Degrader-1 is a dual-target PROTAC degrader with DC50 values of 8.8 pM (BRD4), 6.55 nM (CBP), and 1.05 nM (p300). PROTAC CBP/p300/BRD4 Degrader-1 induces CRBN- and proteasome-dependent degradation of BRD4 and CBP/p300, downregulates c-Myc and acetyl-H3K27, induces apoptosis. PROTAC CBP/p300/BRD4 Degrader-1 acts as an antiproliferative and antitumor agent, induces tumor growth inhibition in xenograft models. PROTAC CBP/p300/BRD4 Degrader-1 can be used for the research of prostate cancer and colorectal cancer[1].
