HPK1-IN-68, CAS [[3078477-58-1]] Preis auf Anfrage

Produktübersicht

• Artikelname: HPK1-IN-68, CAS [[3078477-58-1]] Preis auf Anfrage
• Artikelnummer: MCE-HY-181924
• Hersteller Artikelnummer: HY-181924
• Alternativnummer: MCE-HY-181924-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

HPK1-IN-68 (Compound 39) is a HPK1 inhibitor with an IC50 of 2.8 nM. HPK1-IN-68 blocks HPK1 signaling, inhibits HPK1-mediated phosphorylation of SLP76, and promotes the production of the IL-2 cytokine. HPK1-IN-68 antagonizes the immunosuppressive effect mediated by PGE2. HPK1-IN-68 enhances the infiltration of CD3+/CD8+ T cells into tumor tissues. HPK1-IN-68 exerts T cell-dependent antitumor efficacy in a mouse colon cancer model. HPK1-IN-68 exhibits significant synergistic antitumor effects when used in combination with anti-PD-1. HPK1-IN-68 is applicable to research related to colon cancer[1].

Produkteigenschaften

• Molekulargewicht: 453.51
• CAS Nummer: [3078477-58-1]
• Formel: C23H28FN7O2
• Target-Kategorie: Interleukin Related,MAP4K

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound