ATOX1-IN-1 is an inhibitor of ATOX1 (a copper chaperone protein) with a Kd value of 12.5 µM. ATOX1-IN-1 induces intracellular copper accumulation, increases the level of DNA methylation in the NOTCH1 promoter region, and inhibits the NOTCH1/HES1 signaling pathway. ATOX1-IN-1 enhances the sensitivity of hepatocellular carcinoma cells to Cisplatin (HY-17394). ATOX1-IN-1 can be used in hepatocellular carcinoma-related research[1].
Molekulargewicht:
546.57
CAS Nummer:
[956181-19-4]
Formel:
C33H26N2O6
Target-Kategorie:
Notch
Anwendungsbeschreibung:
MCE Product type: Reference compound
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