NNMT-IN-8 is a non-SAM-mimicking bisubstrate inhibitor and a selective methyltransferase NNMT inhibitor, with IC50 values of 0.0084 µM and 0.0085 µM against human NNMT, and an IC50 of 0.0072 µM against mouse NNMT. NNMT-IN-8 exhibits prominent renal distribution characteristics and moderate bioavailability in rodents. NNMT-IN-8 dose-dependently inhibits renal NNMT in renal fibrosis models, thereby exerting antifibrotic effects. NNMT-IN-8 can be used to investigate the mechanisms of renal fibrosis[1].
Molekulargewicht:
440.53
Formel:
C23H25FN4O2S
Target-Kategorie:
Amine N-methyltransferase
Anwendungsbeschreibung:
MCE Product type: Reference compound
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