NFI23 is a GluN2B-NMDAR inhibitor with an IC50 of 1.31 µM and a Ki of 5.98 nM against GluN2B-NMDAR. NFI23 can cross the blood-brain barrier. NFI23 binds to the ifenprodil binding site of GluN2B-NMDAR, reduces NMDA-induced Ca2+ influx and reactive oxygen species (ROS) production, maintains mitochondrial membrane potential, inhibits neuronal apoptosis, and restores the expression of p-ERK1/2. NFI23 exerts neuroprotective effects against NMDA-induced cytotoxicity and in the rat middle cerebral artery occlusion (MCAO) model. NFI23 can be used for the research of ischemic stroke[1].
Molekulargewicht:
464.56
Formel:
C29H28N4O2
Target-Kategorie:
iGluR
Anwendungsbeschreibung:
MCE Product type: Reference compound
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