WS-691 is an orally active, selective ABCB1 modulator. WS-691 selectively stabilizes ABCB1 via direct binding to ABCB1. WS-691 inhibits the efflux function of ABCB1 and activates ABCB1 ATPase activity. WS-691 elevates intracellular Paclitaxel (HY-B0015) levels and reduces the required dose of Paclitaxel in cancer cells overexpressing ABCB1. WS-691 increases the sensitivity of colon cancer cells to Paclitaxel[1][2].
Molekulargewicht:
405.45
CAS Nummer:
[2035417-32-2]
Formel:
C20H16FN7S
Target-Kategorie:
P-glycoprotein
Anwendungsbeschreibung:
MCE Product type: Reference compound
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