DM245 is an EPAC1 activator and STAT3 phosphorylation inhibitor with a target pIC50 of 4.801. DM245 activates EPAC1 to increase Rap1-GTP levels, with no activation of EPAC2 or PKA. DM245 reduces IL-6/IL-6Ralpha-evoked STAT3 phosphorylation in endothelial cells. DM245 suppresses TGF-beta1-induced fibroblast-to-myofibroblast transition, reducing alphaSMA and Collagen I levels. DM245 exhibits minimal cytotoxicity in normal human lung fibroblasts, with negligible loss of intact nuclei after 72 h exposure[1].
Molekulargewicht:
415.44
CAS Nummer:
[3106606-60-1]
Formel:
C25H21NO5
Target-Kategorie:
Acyltransferase,STAT
Anwendungsbeschreibung:
MCE Product type: Reference compound
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