CP 71362 is a renin inhibitor, a highly potent substrate-analog transition state mimic with antihypertensive properties. CP 71362 exhibits significant inhibitory activity against plasma renin from rats, dogs, and humans (IC50 values are 3 nM, 0.0033 nM, and 20 nM, respectively). CP 71362 reduces the mean arterial pressure of anesthetized and conscious sodium-depleted animals in a dose-dependent manner, and has pharmacokinetic characteristics of rapid elimination and short duration of action. CP 71362 can be used in research related to hypertension and congestive heart failure[1][2].
Molekulargewicht:
945.20
CAS Nummer:
[112227-15-3]
Formel:
C51H76N8O9
Target-Kategorie:
Renin
Anwendungsbeschreibung:
MCE Product type: Reference compound
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