As48 is a selective TREM2 agonist with a KD value of 12.48 µM in TRIC binding assay. As48 binds near the TREM2 cleavage region, forms hydrogen bonds with Gly68, reduces conformational flexibility in regions 58-102, restricts protease accessibility to the cleavage site. As48 activates SYK phosphorylation, enhances microglial phagocytosis, and induces downstream calcium signaling in TREM2-expressing cells. As48 inhibits TREM2 ectodomain shedding without affecting ADAM10/17 protease activities. As48 can be used for the research of Alzheimers disease[1].
Molekulargewicht:
345.42
CAS Nummer:
[1214405-38-5]
Formel:
C20H15N3OS
Target-Kategorie:
Syk,TREM receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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