JWX-A0108 is a selective human alpha7 nAChR positive allosteric modulator with an EC50 of 4.35 µM. JWX-A0108 potentiates alpha7 nAChR currents only in the presence of acetylcholine, with no direct activating effect or alteration of desensitization. JWX-A0108 enhances hippocampal GABAergic synaptic transmission by increasing spontaneous inhibitory postsynaptic currents. JWX-A0108 reduces the brain expression levels of IL-1beta, TNF-alpha, and IL-6 by blocking the NF-kappaB signaling pathway, and reduces microglial activation by downregulating Iba1. JWX-A0108 effectively improves cognitive deficits, neuroinflammation, and hippocampal neuronal damage in mouse models of schizophrenia and Alzheimers disease. JWX-A0108 can be used for research related to schizophrenia and Alzheimers disease[1][2][3].
Molekulargewicht:
400.86
CAS Nummer:
[2055045-42-4]
Formel:
C19H14ClFN4OS
Target-Kategorie:
Interleukin Related,nAChR,NF-kappaB,TNF Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
