AMX-883 a selective and orally active BRD9 molecular glue degrader that drives differentiation in acute myeloid leukaemia. AMX-883 shows selectivity over all other bromodomain containing proteins and proteome wide. AMX-883 does not employ the commonly used E3 ligases (cereblon, VHL) but instead drives degradation via DCAF16 as a targeted glue. AMX-883 can be used for the study of acute myeloid leukaemia (AML)[1].
Molekulargewicht:
767.97
CAS Nummer:
[3102636-19-8]
Formel:
C45H58FN5O5
Target-Kategorie:
Epigenetic Reader Domain,Molecular Glues
Anwendungsbeschreibung:
MCE Product type: Reference compound
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