MAO-B-IN-56 is a multi-target-directed ligand with AChE, BChE, MAO-B, and BACE1 inhibitory activity, with IC50 values of 0.35 µM, 3.22 µM, 0.14 µM, and 3.85 µM respectively, and shows selectivity for AChE over BChE and MAO-B over MAO-A.MAO-B-IN-56 reduces amyloid-beta production, reduces paw edema, improves spatial memory, and enhances Alzheimers disease hallmarks and associated histopathological alterations.MAO-B-IN-56 can be used for the research of alzheimers disease[1].
