IBA-11 is a selective CRBN-dependented CK1alpha molecular glue degrader. IBA-11 binds to the canonical tri-tryptophan pocket of CRBN, forming a ternary complex with CK1alpha to mediate its degradation. IBA-11 induces CRBN-dependent ubiquitin-proteasome system-mediated degradation of CK1alpha. IBA-11 exhibits cytotoxicity against cancer cells. IBA-11 demonstrates in vitro metabolic stability in rat liver microsomes and minimal hERG inhibition. IBA-11 can be used for the research of cancer, such as acute myeloid leukemia[1].
Molekulargewicht:
437.40
Formel:
C22H17F2N5O3
Target-Kategorie:
Casein Kinase,Molecular Glues
Anwendungsbeschreibung:
MCE Product type: Reference compound
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