UCUF-965 is a CXCR4 positive allosteric modulator. UCUF-965 potentiates CXCL12-induced beta-arrestin recruitment and cAMP signaling, activates lymphoblast migration, induces calcium flux, and does not bind CXCR4s orthosteric CXCL12 site. UCUF-965 reduces miR-15b and miR-29a levels, increases miR-146a levels in fibroblasts. UCUF-965 enhances angiogenesis and reduces wound healing time in diabetic mice. UCUF-965 can be used for the research of diabetic wound healing impairment[1].
Molekulargewicht:
405.52
CAS Nummer:
[2965316-77-0]
Formel:
C22H23N5OS
Target-Kategorie:
Arrestin,Calcium Channel,CXCR
Anwendungsbeschreibung:
MCE Product type: Reference compound
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