KRASG12C IN-20 is an orally potent KRASG12C inhibitor with an EC50 of 3.9 nM. KRASG12C IN-20 covalently modifies KRASG12C in its inactive GDP-bound state and locks it to block oncogenic signal transduction. KRASG12C IN-20 exhibits significant activity in lung adenocarcinoma xenograft models. KRASG12C IN-20 can be used for research related to lung adenocarcinoma[1].
Molekulargewicht:
674.72
Formel:
C35H37F3N8O3
Target-Kategorie:
Ras
Anwendungsbeschreibung:
MCE Product type: Reference compound
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