UM-200 is a covalent STING inhibitor with an EC50 of 1.10 µM. UM-200 covalently modifies the cysteine residues C292 or C309 of STING, thereby blocking its oligomerization and downstream signal transduction. UM-200 inhibits STING-dependent phosphorylation of TBK1 and IRF3. UM-200 inhibits the STING signaling pathway in mouse models. UM-200 can be used for research on STING-driven inflammatory and autoimmune diseases[1].
Molekulargewicht:
443.52
Formel:
C24H21N5O2S
Target-Kategorie:
STING
Anwendungsbeschreibung:
MCE Product type: Reference compound
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