KLHL12 ligand-1 is a KLHL12 Kelch domain ligand with a Ki of 0.33 µM, Ka of 0.33 µM, submicromolar binding affinity, and selective binding over KEAP1/KLHL19. KLHL12 ligand-1 binds in the substrate cleft of KLHL12, with its 4-methyl group forming a CH-pi interaction with Tyr334. KLHL12 ligand-1 binds to cellular KLHL12 in permeabilized and intact cells, and has solvent-exposed positions suitable for modification to create PROTACs. KLHL12 ligand-1 can be used for the research of cancer[1].
Molekulargewicht:
383.66
Formel:
C16H13Cl3N4O
Target-Kategorie:
Others
Anwendungsbeschreibung:
MCE Product type: Reference compound
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