SMARCA2/SMARCA4 ligand-1 is a SMARCA2/SMARCA4 ligand with KD values of 1.2 and 10.3 nM. SMARCA2/SMARCA4 ligand-1 binds SMARCA2/4 bromodomain via hydrogen bonds with asparagine and tyrosine residues, and a salt bridge with a glutamate residue. SMARCA2/SMARCA4 ligand-1 shows antiproliferative activity against cancer cells. SMARCA2/SMARCA4 ligand-1 can be used for the research of cancer, such as smarca4 mutant nonsmall cell lung cancer[1].
Molekulargewicht:
409.28
Formel:
C20H17BrN4O
Target-Kategorie:
Ligands for Target Protein for PROTAC,SWI/SNF Complex
Anwendungsbeschreibung:
MCE Product type: Reference compound
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