LJM133 is a SMARCA2/PBRM1/SMARCA4 PROTAC degrader with DC50 values of 3.5 nM, 7 nM, and 6.4 nM. LJM133 induces ternary complex formation with VHL E3 ligase to drive proteasome-mediated degradation of target proteins. LJM133 suppresses cell proliferation and exhibits significant antitumor efficacy in a SMARCA4 mutant cancer xenograft model. LJM133 can be used for the research of cancer, such as SMARCA4 mutant non-small cell lung cancer[1]. (Pink: SMARCA2/PBRM1/SMARCA4 ligand (HY-182987), E3 ubiquitin ligase ligand-linker conjugate (HY-183619)).
Molekulargewicht:
994.02
Formel:
C51H58BrFN8O5S
Target-Kategorie:
PROTACs,SWI/SNF Complex
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
