MNK1/2-IN-11 is a potent, selective and orally active MNK1/2 inhibitor with MNK1 IC50 of 1.2 nM, MNK2 IC50 of 1.3 nM. MNK1/2-IN-11 reduces eukaryotic translation initiation factor 4E phosphorylation, decreases Mcl-1 and Cyclin D1 expression. MNK1/2-IN-11 inhibits tumor growth in mouse CT26 colorectal tumor models. MNK1/2-IN-11 can be used for the research of colorectal cancer[1].
Molekulargewicht:
537.61
Formel:
C30H31N7O3
Target-Kategorie:
Bcl-2 Family,MNK
Anwendungsbeschreibung:
MCE Product type: Reference compound
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