BuChE-IN-23, CAS [[3067571-93-8]] Preis auf Anfrage
Artikelnummer:
MCE-HY-183352
Hersteller Artikelnummer:
HY-183352
Alternativnummer:
MCE-HY-183352-1UNIT
Hersteller:
MedchemExpress
Kategorie:
Biochemikalien
BuChE-IN-23 is an orally active, blood-brain barrier permeable butyrylcholinesterase (eqBuChE) inhibitor with an IC50 of 15.59 µM and a Ki of 29.33 µM. BuChE-IN-23 exhibits an IC50 of 38.65 µM against hBuChE and shows selectivity for butyrylcholinesterase over acetylcholinesterase. BuChE-IN-23 inhibits LPS (HY-D1056)-induced nitric oxide production, attenuates hippocampal glial cell activation and neuroinflammation, suppresses the TLR4/p38 MAPK signaling pathway, and regulates the IL-1beta/C3-mediated microglia-astrocyte inflammatory axis. BuChE-IN-23 can be used for the research of Alzheimers disease[1].
