MS108 is a selective VHL-based eleven-nineteen leukemia protein (ENL) PROTAC degrader with DC50 of 0.6 nM. MS108 recruits VHL E3 ligase to induce ENL degradation in a VHL- and ubiquitin-proteasome system (UPS)-dependent manner. MS108 degrades the ENL paralog AF9, which shares a highly conserved YEATS domain with ENL. MS108 suppresses proliferation of cancer cells[1].
Molekulargewicht:
1041.27
Formel:
C56H68N10O8S
Target-Kategorie:
Epigenetic Reader Domain,PROTACs
Anwendungsbeschreibung:
MCE Product type: Reference compound
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