CSF1R-IN-27, CAS [[3034296-91-5]] Preis auf Anfrage
Artikelnummer:
MCE-HY-183569
Hersteller Artikelnummer:
HY-183569
Alternativnummer:
MCE-HY-183569-1UNIT
Hersteller:
MedchemExpress
Kategorie:
Biochemikalien
CSF1R-IN-27 is a CSF1R inhibitor with oral effectiveness, kinome-wide selective profile, low cellular cytotoxicity, and CSF1R IC50 values of 19 nM, 88 nM, 173 nM, 797 nM, 1448 nM, and >3000 nM. CSF1R-IN-27 suppresses M-CSF-induced phosphorylation of CSF1R, AKT, and ERK in macrophages, and inhibits hepatic p-CSF1R/p-AKT/p-ERK signaling. CSF1R-IN-27 reduces serum transaminase levels, improves hepatic histopathology, alleviates inflammatory cell infiltration, and decreases circulating TNF-alpha and IL-6 levels. CSF1R-IN-27 can be used for the research of acute liver injury[1].
