SUCNR1 antagonist-1 is an orally active SUCNR1 antagonist. SUCNR1 antagonist-1 forms stable, water-bridged hydrogen bonds with key residue Glu221.31 to stabilize binding conformation and modulates protein conformational flexibility. SUCNR1 antagonist-1 blocks succinate-mediated SUCNR1 signaling and induces cell apoptosis. SUCNR1 antagonist-1 can be used for the research of colorectal carcinoma[1].
Molekulargewicht:
411.45
Formel:
C26H21NO4
Target-Kategorie:
Apoptosis,Succinate Receptor 1
Anwendungsbeschreibung:
MCE Product type: Reference compound
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