ISR activator-4 is an eIF2B modulator and integrated stress response (ISR) activator with a human eIF2B EC50 of 2.2 µM. ISR activator-4 stabilises the inactive I-state of eIF2B, favours formation of the inhibitory eIF2B-eIF2(alphaP) complex, and attenuates eIF2Bs guanine nucleotide exchange factor activity. ISR activator-4 can be used for the research of cancer, neurologic and metabolic disorders[1].
Molekulargewicht:
563.63
Formel:
C30H37F4N3O3
Target-Kategorie:
Eukaryotic Initiation Factor (eIF),Mitogen- and Stress-Activated Protein Kinase (MSK)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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