RORgammat inverse agonist 37 is an orally active RORgammat inverse agonist with an IC50 of 10.8 nM against human targets. RORgammat inverse agonist 37 destabilizes helix 12 of RORgammat in the agonist-bound conformation, thereby inhibiting transcriptional activity. RORgammat inverse agonist 37 inhibits the secretion of IL-17 in cells and in LPS-induced systemic inflammation mouse models. RORgammat inverse agonist 37 improves disease-related symptoms in mouse models of psoriasiform dermatitis. RORgammat inverse agonist 37 can be used in research related to psoriasiform dermatitis and systemic inflammation[1].
Molekulargewicht:
640.66
Formel:
C31H33F5N2O5S
Target-Kategorie:
Interleukin Related,ROR
Anwendungsbeschreibung:
MCE Product type: Reference compound
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