NEK7 degrader-3, CAS [[3119435-52-5]] Preis auf Anfrage
Artikelnummer:
MCE-HY-185311
Hersteller Artikelnummer:
HY-185311
Alternativnummer:
MCE-HY-185311-1UNIT
Hersteller:
MedchemExpress
Kategorie:
Biochemikalien
NEK7 degrader-3 is an orally active and brain-penetrant NEK7 molecular glue degrader with a DC50 of 33.1 nM. NEK7 degrader-3 mediates interaction between NEK7 and E3 ligase cereblon, promoting proteasomal degradation of NEK7 and attenuating NLRP3 inflammasome-mediated inflammatory responses. NEK7 degrader-3 inhibits caspase-1 activity, cytokine release of IL-1beta, IL-1alpha, and IL-18, and pyroptosis-related plasma membrane permeabilization. NEK7 degrader-3 shows antiinflammatory activity in an LPS (HY-D1056)-induced neuroinflammation mouse model. NEK7 degrader-3 can be used for the research of neuroinflammation[1].
