UCP1172 is an antibacterial (Antibacterial) agent and Dihydrofolate reductase inhibitor, with an IC50 of 0.0089 µM against Staphylococcus aureus DfrB, 0.22 µM against DfrG, 0.41 µM against DfrA, and 0.030 µM against DfrK. UCP1172 potently inhibits the growth of MRSA/MSSA isolates carrying dfrG and dfrK (MIC values of 0.3125-0.625 µg/mL), shows weak activity against MRSA carrying dfrA (MIC of 5 µg/mL), and exerts extremely potent inhibitory effects on wild-type S. aureus ATCC 43300 (MIC of 0.0098 µg/mL). UCP1172 can be used in studies related to tuberculosis and Staphylococcus aureus infections[1][2].
Molekulargewicht:
416.47
CAS Nummer:
[1922152-04-2]
Formel:
C24H24N4O3
Target-Kategorie:
Bacterial,Dihydrofolate reductase (DHFR)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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