SB-612111 hydrochloride hydrochloride is a novel and potent opiate receptor-like orphan receptor (ORL-1) antagonist with a high affinity for hORL-1 (Ki=0.33 nM). SB-612111 hydrochloride exhibits selectivity for µ-, kappa- and delta-receptors with Ki values of 57.6 nM, 160.5 nM and 2109 nM, respecticely. SB-612111 hydrochloride effectively antagonizes the pronociceptive action of Nociceptin (HY-P0183) in an acute pain model[1].
Molekulargewicht:
454.86
Reinheit:
99.26
Formel:
C24H30Cl3NO
Target-Kategorie:
Opioid Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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