K-Ras(G12C) inhibitor 12 is an irreversible inhibitor of K-Ras(G12C). K-Ras(G12C) inhibitor 12 can alter the nucleotide-binding preference of K-Ras and block its interaction with effector proteins. K-Ras(G12C) inhibitor 12 can reduce cell viability and induce apoptosis in lung cancer cell lines with G12C mutations. K-Ras(G12C) inhibitor 12 has anti-tumor activity[1].
Molekulargewicht:
449.67
Reinheit:
99.57
CAS Nummer:
[1469337-95-8]
Formel:
C15H17ClIN3O3
Target-Kategorie:
Apoptosis,Ras
Anwendungsbeschreibung:
MCE Product type: Reference compound
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