KAI-407 is an orally active inhibitor of Plasmodium PI4K kinase, which can broadly inhibit multiple stages of the parasite lifecycle. KAI-407 exhibits EC50s of for the blood stage of malignant Plasmodium of 81 nM, for the liver schizonts of P. yoelii of 88 nM, and IC50s for the liver schizonts and dormant bodies of P. cynomolgi of 0.64 µM and 0.69 µM respectively. KAI-407 can prevent Plasmodium berghei infection 100%. KAI-407 can be used for the study of vivax malaria[1][2].
Molekulargewicht:
421.37
CAS Nummer:
[1513879-18-9]
Formel:
C22H14F3N5O
Target-Kategorie:
Parasite,PI4K
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
