(E/Z)-Icerguastat hydrochloride ((E/Z)-Sephin1 hydrochloride) is a selective inhibitor with activity that prolongs the phosphorylation effects of eIF2alpha. (E/Z)-Icerguastat hydrochloride protects cells from defects in proteostasis. (E/Z)-Icerguastat hydrochloride was shown to significantly extend the survival of infected prion mice in a mouse model. (E/Z)-Icerguastat hydrochloride effectively reduces PrPSc expression and prion sequence activity in various neuronal cell lines persistently infected with different prion strains[1].
Molekulargewicht:
233.10
CAS Nummer:
[32597-86-7]
Formel:
C8H10Cl2N4
Target-Kategorie:
Phosphatase
Anwendungsbeschreibung:
MCE Product type: Reference compound
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