RG-7152 is a tetrazolyl-substituted leukotriene D4 receptor antagonist that can induce peroxisomal beta-oxidation and peroxisome bifunctional enzymes (PBEs) in hepatocytes in various animal models. It has been shown to significantly increase PBE levels and beta-oxidation activity in rat and mouse liver homogenates, while smaller effects were observed in guinea pigs and monkeys and no effect in dogs. In vitro studies have also shown that it can induce PBEs comparable to clofibric acid, indicating its potential as a peroxisome proliferator[1].
Molekulargewicht:
361.40
CAS Nummer:
[107813-63-8]
Formel:
C20H19N5O2
Target-Kategorie:
Leukotriene Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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