PD-134672 (CI-992) is a renin inhibitor containing a 2-amino-4-thiazolyl substituent. PD-134672 potently inhibits monkey renin in vitro and only weakly inhibits the related aspartic protease bovine feline hepsin D. The compound exhibits oral hypotensive activity in hyperreninemic normotensive monkeys. Based on its superior efficacy and long-lasting effects in vitro and in the normotensive macaque model, PD-134672 was selected for further evaluation in renal hypertensive monkeys.
Molekulargewicht:
708.93
CAS Nummer:
[135704-06-2]
Formel:
C33H52N6O7S2
Target-Kategorie:
Renin
Anwendungsbeschreibung:
MCE Product type: Reference compound
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