L-685458, CAS [[292632-98-5]]

Produktübersicht

• Artikelname: L-685458, CAS [[292632-98-5]]
• Artikelnummer: MCE-HY-19369
• Hersteller Artikelnummer: HY-19369
• Alternativnummer: MCE-HY-19369-50MG,MCE-HY-19369-25MG,MCE-HY-19369-10MG,MCE-HY-19369-5MG,MCE-HY-19369-10MMX1ML,MCE-HY-19369-1MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: L-685,458

Produktbeschreibung

L-685458 is a potent transition state analog (TSA) gamma-secretase inhibitor (GSI). L-685458 inhibits amyloid beta-protein precursor gamma-secretase activity with IC50 of 17 nM, shows greater than 50-100-fold selectivity over other aspartyl proteases tested. L685458 inhibits gamma-secretase-mediated cleavage of APP-C99 and Notch-100 with IC50s of 301.3 nM and 351.3 nM, respectively. L-685458 can be used for the research of alzheimers disease (AD) and cancers[1][2].

Produkteigenschaften

• Molekulargewicht: 672.85
• Reinheit: 99.69
• CAS Nummer: [292632-98-5]
• Formel: C39H52N4O6
• Target-Kategorie: Apoptosis,gamma-secretase

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound