BMS-223131 (Compound 1) is a potent maxi-K potassium channel opener. BMS-223131 has a strong inhibitory effect on the CYP2C9 enzyme (IC50 = 1.7 µM) and also shows varying degrees of inhibition on other common CYP enzymes such as CYP1A2, CYP2C19, CYP2D6, and CYP3A4. BMS-223131 can enhance the outward current mediated by maxi-K, by promoting K+ efflux to hyperpolarize the cell membrane and reducing Ca2+ influx. BMS-223131 can be used for the research of neurological disease, such as stroke[1].
Molekulargewicht:
383.75
CAS Nummer:
[275375-69-4]
Formel:
C18H13ClF3NO3
Target-Kategorie:
Cytochrome P450,Potassium Channel
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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