GS-9667 (CVT 3619), a novel N6-5-substituted adenosine analog, is a selective, partial agonist of the A1 adenosine receptor (A1AdoR). GS-9667 binds to adipocyte membranes with high (KH=14 nM) and low (KL=5.4 µM) affinities. GS-9667 reduces cyclic AMP content and release of nonesterified fatty acids from epididymal adipocytes with IC50 values of 6 nM and 44 nM, respectively. GS-9667 inhibits lipolysis and has the potential for Type 2 diabetes (T2DM) and dyslipidemia via lowering of free fatty acids (FFA)[1][2].
Molekulargewicht:
461.51
Reinheit:
98.08
CAS Nummer:
[618380-90-8]
Formel:
C21H24FN5O4S
Target-Kategorie:
Adenosine Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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