Burixafor (TG-0054) is a potent CXCR4 antagonist with a pIC50 of 7.4. Burixafor inhibits the binding of CXCL12 to CXCR4, antagonizes CXCL12-induced recruitment of Galpha and beta-arrestin2, and blocks the downstream Galpha-mediated inhibitory effect on cAMP signal transduction. Burixafor mobilizes CD34+ hematopoietic stem/progenitor cells (HSPC) from the bone marrow to the peripheral blood. Burixafor can be used for research on autologous hematopoietic stem cell transplantation (ASCT)[1][2].
Molekulargewicht:
566.72
CAS Nummer:
[1191448-17-5]
Formel:
C27H51N8O3P
Target-Kategorie:
CXCR
Anwendungsbeschreibung:
MCE Product type: Reference compound
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