SHOC2-RAS PPI-IN-1 (compound 6) is a non-covalent competitive inhibitor targeting the interaction between SHOC2 and RAS proteins. SHOC2-RAS PPI-IN-1 has an IC50 of 0.048 µM and a KD of 0.065 µM for NRASQ61R. SHOC2-RAS PPI-IN-1 can inhibit the activity of the SMP phosphatase complex, leading to increased CRAFS259 phosphorylation levels, thereby blocking the MAPK signaling pathway (such as reducing the levels of pMEK and pERK), inducing tumor cell cycle arrest and apoptosis. SHOC2-RAS PPI-IN-1 can be used for targeted research on malignant tumors such as melanoma and colorectal cancer with NRASQ61R mutations[1].
Molekulargewicht:
494.28
Reinheit:
99.50
Formel:
C20H19IN2O5
Target-Kategorie:
Apoptosis,Ras
Anwendungsbeschreibung:
MCE Product type: Reference compound1
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
