3-Methoxy-4-nitroflavone, CAS [[145370-39-4]] Preis auf Anfrage
Artikelnummer:
MCE-HY-20888
Hersteller Artikelnummer:
HY-20888
Alternativnummer:
MCE-HY-20888-1UNIT
Hersteller:
MedchemExpress
Kategorie:
Biochemikalien
Alternative Synonym:
MNF
3-Methoxy-4-nitroflavone (MNF) is a specific aryl hydrocarbon receptor (AhR) antagonist. 3-Methoxy-4-nitroflavone activates AhR by inhibiting CYP1, the metabolic enzyme of the endogenous ligand FICZ (HY-12451), leading to the accumulation of FICZ. 3-Methoxy-4-nitroflavone reverses the anti-apoptotic effect of TCDD, attenuates the activation of Akt and Erk1/2 kinases and the expression of TGFalpha induced by TCDD. 3-Methoxy-4-nitroflavone can be used in research related to breast tumor promotion, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease[1][2].
