Avagacestat (Standard) is the analytical standard of Avagacestat. This product is intended for research and analytical applications. Avagacestat (BMS-708163) is a potent inhibitor of gamma-secretase, with IC50s of 0.27 nM and 0.30 nM for Abeta42 and Abeta40 inhibition, Avagacestat (BMS-708163) also inhibits NICD (Notch IntraCellular Domain) with IC50 of 0.84 nM and shows weak inhibition of CYP2C19, with IC50 of 20 µM. Avagacestat can be used for Alzheimer disease research.
Molekulargewicht:
520.89
CAS Nummer:
[1146699-66-2]
Formel:
C20H17ClF4N4O4S
Target-Kategorie:
Notch,Reference Standards,gamma-secretase
Anwendungsbeschreibung:
MCE Product type: Reference Standards
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
