Gefitinib hydrochloride (ZD1839 hydrochloride) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib hydrochloride selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib hydrochloride also induces autophagy. Gefitinib hydrochloride has antitumour activity[1][2].
Molekulargewicht:
483.36
Reinheit:
99.85
CAS Nummer:
[184475-55-6]
Formel:
C22H25Cl2FN4O3
Target-Kategorie:
EGFR
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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