Ac-Exatecan is acetylation-modified Exatecan (HY-13631). Exatecan is a common toxin component in ADC preparation (ADC cytotoxin) and an inhibitor of DNA topoisomerase I (IC50 = 2.2 µM). Exatecan has antitumor activity. Exatecan can be used as a payload for ADC. Exatecan is effective against P-glycoprotein mediated multi-drug resistant cells[1][2].
Molekulargewicht:
477.48
Reinheit:
99.02
CAS Nummer:
[2922852-48-8]
Formel:
C26H24FN3O5
Target-Kategorie:
ADC Payload,Topoisomerase
Anwendungsbeschreibung:
MCE Product type: Reference compound
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