Lenalidomide-13C5,15N is 15N and 13C labeled Lenalidomide (HY-A0003). Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells[1][2].
Molekulargewicht:
265.22
Formel:
C8 13C5H13N2 15NO3
Target-Kategorie:
Apoptosis,Isotope-Labeled Compounds,Ligands for E3 Ligase,Molecular Glues
Anwendungsbeschreibung:
MCE Product type: Isotope-Labeled Compounds
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