Dexbrompheniramine ((+)-Brompheniramine, (S)-Brompheniramine) is a dual inhibitor of histamine H1 receptor and TRPV1 receptor that can cross the blood-brain barrier. Dexbrompheniramine exerts its effects by functionally blocking H1 receptor activity and dose-dependently inhibiting TRPV1-mediated calcium responses, including Capsaicin (HY-10448)-induced responses. The combination of Dexbrompheniramine with Cimetidine (HY-14289) eliminates histamine-induced and sham-feeding-induced drinking behavior, whereas Dexbrompheniramine alone does not induce thirst or alter sham-feeding behavior in rats. Dexbrompheniramine can be used in the research of chronic cough and related pathological mechanisms[1][2][3].
Molekulargewicht:
319.24
Reinheit:
99.60
CAS Nummer:
[132-21-8]
Formel:
C16H19BrN2
Target-Kategorie:
Histamine Receptor,TRP Channel
Anwendungsbeschreibung:
MCE Product type: Reference compound
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