Formoterol fumarate (Formoterol) is a potent, selective and long-acting beta2-adrenoceptor agonist. IC50 Value: 2.1 nM in pregnant C3H/HeN strain mice[5] Target: beta2 receptor Budesonide/formoterol in a single inhaler for both maintenance and reliever therapy is now an established therapeutic option for management of inadequately controlled asthma[4]. in vitro:. The long-acting beta(2)-agonist formoterol and the glucocorticoid dexamethasone significantly reduced HRV-induced ERK phosphorylation, Fra-1, and MMP-9 expression in BEAS-2B cells[3]. in vivo: compared the bronchodilatory effects of inhaled budesonide/formoterol (dose: 200 µg and 12 µg respectively) combination with budesonide (200 µg)/salbutamol (200 µg) administered by metered dose inhaler and spacer in children of 5-15 years with mild acute exacerbation of asthma [Modified Pulmonary Index Score (MPIS) between 6-8] in this double-blind, randomized controlled trial. The primary outcome was FEV1 (% predicted) in the two groups at 1, 5, 15, 30, 60 min after administration of the study drug[1]. Fifteen randomized, placebo-controlled clinical trials including COPD patients were evaluated: indacaterol 75 µg once daily (n = 2 studies), indacaterol 150 µg once daily (n = 5), indacaterol 300 µg once daily (n = 4), FOR/BUD 9/160 µg twice daily (n = 2), FOR/BUD 9/320 µg twice daily (n = 2), SAL/FP 50/500 µg twice daily (n = 4), and SAL/FP 50/250 µg twice daily (n = 1)[2]. Clinical trial: Effects of Mometasone Furoate/Formoterol Combination Versus Mometasone Furoate Alone in Persistent Asthmatics (Study P04073) . Phage3
Molekulargewicht:
402.44
Reinheit:
99.95
CAS Nummer:
[43229-80-7]
Formel:
C19H24N2O4.1/2C4H4O4
Target-Kategorie:
Adrenergic Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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