Estradiol (beta-Estradiol) hemihydrate is a steroid hormone and the major female sex hormone. Estradiol (beta-Estradiol) hemihydrate can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol (beta-Estradiol) hemihydrate can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering[1][2].